Generally Danfoss recommends to replace the R22 systems with new ones, using alternative refrigerants.
The main arguments to build new systems are:
• Higher reliability of new systems
• Higher efficiency / energy savings
• Lower service costs / warranty on system
• Reduced carbon footprint
However, if you have to use drop-in replacements of R22, on this page you can find a few Danfoss recommendations on what you can do. Danfoss takes no liability in case of malfunction of the systems with drop-in refrigerants.